منابع مشابه
Central and Metabolic Effects of High Fructose Consumption: Evidence from Animal and Human Studies
Fructose consumption has increased dramatically in the last 40 years, and its role in the pathogenesis of the metabolic syndrome has been implicated by many studies. It is most often encountered in the diet as sucrose (glucose and fructose) or high-fructose corn syrup (55% fructose). At high levels, dietary exposure to fructose triggers a series of metabolic changes originating in the liver, le...
متن کاملEditorial: Schizophrenia: Human and Animal Studies
Schizophrenia is a complex disorder with relatively stable prevalence rates estimated at about 0.5–1% (Saha et al., 2005). Schizophrenia is characterized by the occurrence of various psychopathological symptoms that have been described as positive symptoms (delusions and hallucinations), negative symptoms (apathy, lack of motivation, flat affect, poverty of speech, and social withdrawal), disor...
متن کاملAnimal carcinogenicity studies: 1. Poor human predictivity.
The regulation of human exposure to potentially carcinogenic chemicals constitutes society's most important use of animal carcinogenicity data. Environmental contaminants of greatest concern within the USA are listed in the Environmental Protection Agency's (EPA's) Integrated Risk Information System (IRIS) chemicals database. However, of the 160 IRIS chemicals lacking even limited human exposur...
متن کاملComparability of human and animal studies of developmental cocaine exposure.
Human and animal studies of cocaine exposure during development can be compared on many levels and from many different perspectives. The most logical place to begin is to pose the question: What is the best animal model for cocaine abuse during pregnancy, and does the information obtained in a given animal model apply to humans? Of course, due to the complex nature of cocaine’s pharmacology, th...
متن کاملSafety of pyridoxine--a review of human and animal studies.
A literature review was conducted on adverse effects associated with administration of high oral doses of pyridoxine (vitamin B6) to animals and man. The human data suggest that doses of pyridoxine greater than 500 mg/day for prolonged periods of time can result in sensory nerve damage. Doses less than 500 mg/day appear to be safe on the basis of literature reports where the compound was admini...
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ژورنال
عنوان ژورنال: Statistical Science
سال: 1988
ISSN: 0883-4237
DOI: 10.1214/ss/1177012830